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M94A0192.TXT
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1994-10-08
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Document 0192
DOCN M94A0192
TI Use of antineutrophil cytoplasmic autoantibodies in diagnosing
vasculitis in a Chinese patient population.
DT 9412
AU Li PK; Leung JC; Lai FM; Wang A; Lui SF; Leung CB; Lai KN; Department of
Medicine, Chinese University of Hong Kong, Prince; of Wales Hospital,
Shatin.
SO Am J Nephrol. 1994;14(2):99-105. Unique Identifier : AIDSLINE
MED/94361175
AB Antineutrophil cytoplasmic autoantibodies (ANCA) have been used as
markers of systemic vasculitides, including microscopic polyarteritis
(MPA) and Wegener's granulomatosis. The diagnostic potential of ANCA
assays together with antibodies against the neutrophil enzymes
myeloperoxidase (MPO) and proteinase 3 for detecting a systemic
vasculitis was tested in a Chinese patient population. 672 sera were
received for ANCA assay, and ANCA detected by indirect
immunofluorescence was positive in 73 sera from 42 patients. Of the 42
patients, 3 had cytoplasmic ANCA, while 39 had a perinuclear pattern.
There was no patient with Wegener's granulomatosis. Two cytoplasmic ANCA
positive patients suffered from ulcerative colitis. Another cytoplasmic
ANCA positive patient was a carrier of human immunodeficiency virus. Of
the 39 perinuclear ANCA positive patients, 10 had MPA. Eight of them
were tested for anti-MPO antibody, and all were positive. Other immune
disorders that were perinuclear ANCA positive included: 13 patients with
systemic lupus erythematosus, 3 with mixed connective tissue disease, 1
with Goodpasture's syndrome, 2 with inflammatory bowel disease, and 2
patients with IgA nephropathy. Anti-MPO antibody was not specific for
MPA, and 7 out of the 13 patients with systemic lupus erythematosus were
anti-MPO antibody positive. Our study suggests that ANCA and anti-MPO
antibody are not specific for MPA in a Chinese population. They would
alert the clinician of the possibility of vasculitis, but a
clinicopathological correlation is essential in making the diagnosis.
DE Adolescence Adult Aged Autoantibodies/BLOOD/*IMMUNOLOGY Biological
Markers/BLOOD China Colitis, Ulcerative/BLOOD/DIAGNOSIS/IMMUNOLOGY
Cytoplasm/IMMUNOLOGY Female Fluorescent Antibody Technique
Glomerulonephritis, IGA/BLOOD/DIAGNOSIS/IMMUNOLOGY Goodpasture's
Syndrome/BLOOD/DIAGNOSIS/IMMUNOLOGY Human HIV
Infections/BLOOD/DIAGNOSIS/IMMUNOLOGY Inflammatory Bowel
Diseases/BLOOD/DIAGNOSIS/IMMUNOLOGY Lupus Erythematosus,
Systemic/BLOOD/DIAGNOSIS/IMMUNOLOGY Male Middle Age Mixed Connective
Tissue Disease/BLOOD/DIAGNOSIS/IMMUNOLOGY
Neutrophils/ENZYMOLOGY/IMMUNOLOGY Periarteritis
Nodosa/BLOOD/DIAGNOSIS/IMMUNOLOGY Peroxidase/METABOLISM Predictive
Value of Tests Serine Proteinases/METABOLISM Support, Non-U.S. Gov't
Vasculitis/BLOOD/*DIAGNOSIS/ETHNOLOGY/IMMUNOLOGY Wegener's
Granulomatosis/BLOOD/DIAGNOSIS/IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).